Dicyclomine is a synthetic tertiary amine derivative that has been widely used in treatment of smooth muscle spasm of the Gastrointestinal tract. As an antispasmodic and antimuscarinic agent, it probably works by specific anticholinergic effect (antimuscarinic) at the acetylcholine (ACh)-receptor sites. Now Dicyclomine tablets and syrups are available in Market. This work was carried out to formulate the chewable tablets (Non liquid dosage form) of dyclocmine. Chewable tablets are the non liquid oral dosage form which are to chewed not swallowed. Geriatric and paediatric patients find it difficult to swallow conventional tablets. So in order to avoid this problem, chewable tablets are most pre-ferable to increase bioavailability and palatability. This is new formualation approch which may be used for further research. The chewable tablets of dicyclomine were prepared by using Mannitol along with cross povidone in different concentration ratios especially for paediatric use. Aspartame and vanilla were used as sweeten-ing agent and flavouring agent respectively. The dissolution studies of dyclomine chewable tablet were performed on pH 1.2 and 6.8 . Chewable tablets that met the pharmacopoeial specifications for tablets, with 88% dissolved amount
